AlphaChisel by Olympus Labs

AlphaChisel by Olympus Labs

Unlock the Power of Metabolic Mastery with AlphaChisel by Olympus Labs 

Unlock a new realm of possibilities in weight management with AlphaChisel—the ultimate fat burner supplement meticulously formulated by Olympus Labs, designed to get you Chiseled! Formulated to revolutionize your fitness journey, AlphaChisel synergistically merges scientifically-backed ingredients to target multiple pathways and mechanisms of action. This isn't just another supplement; it's a groundbreaking fat-loss arsenal, primed to set ablaze your weight loss goals and redefine what's possible. 

It is not just another Fat Burner, it’s formula contains ingredients no one has used in this way ever before. The R&D Department dug deep and located ingredients that make other fat burners look like child’s play. 

Step into a new horizon of fat loss and metabolic efficiency with AlphaChisel, Olympus' magnum opus in the world of weight management. Every capsule is a mosiac of scientifically-proven ingredients, each offering distinct yet interconnected pathways and mechanisims of action to transform your body. AlphaChisel isn't just a supplement; it's a scientific marvel, where each ingredient plays its role to perform in this finely orchestrated symphoney of fat loss. 

Key Benefits of ALPHACHISEL: 

• Decrease Body Fat*
• Increase Energy*
• Increase Thermogenesis*
• Reduce Appetite and Cravings*
• Reduce Cortisol*
• Reduce Fluid Retention*
• Reduce Bloating*
• Reduce Blood Glucose Levels*
• Suppress Fat Storage*
• Improve Focus & Alertness*
• Improve Gut Health*
• Convert White Fat(Stored Fat) to Brown Fat(Ready to Burn Fat)*
• Scientifically Proven Ingredients*
• Can Be Used by Both Men & Women
• Improve insulin sensitivity*
• Improve Muscle Mass*
• Anti-Inflammatory*

In a market saturated with quick fixes and hollow promises, AlphaChisel stands as a beacon of scientific integrity and metabolic innovation. We've transcended traditional weight management solutions by crafting a masterful blend of synergistic ingredients that attack fat loss from multiple angles and pathways. It's not just about shedding pounds; it's about sculpting a more efficient, healthier you. From thermogenesis to gut health, from muscle retention to mental clarity, AlphaChisel is designed to optimize every facet of your weight loss journey. Don't settle for average when extraordinary is within reach. Make the informed choice; elevate your transformation today with AlphaChisel by Olympus Labs. When excellence is an option, why choose anything less? If you want to understand the science behind every ingredient you can read below for the ingredient details, studies and benefits. 

AlphaChisel Ingredients Explanation and Benefits: 

A Symphony of Pathways, Mechanisms, and Synergies

Xanthigen® Fucoxanthin and Brown Seaweed:

1. PPAR Activation: Fucoxanthin activates Peroxisome Proliferator-Activated Receptors (PPARs), particularly PPARα and PPARγ, which orchestrate lipid metabolism and cellular differentiation.

2. BAT Activation: Increases the expression of Uncoupling Protein 1 (UCP1) in brown adipose tissue (BAT), furthering thermogenesis and caloric burn.

3. AMPK Activation: Additionally stimulates the AMPK pathway, enhancing overall energy metabolism.

aXivite® Phenylcapsaicin:

1. Thermogenesis Activation: Stimulates TRPV1 channels, driving thermogenesis and fat oxidation.

2. AMPK Activation: Contributes to weight loss by further activating the AMPK pathway.

3. Serum Zonulin Reduction: Works to reduce gut permeability and inflammation, providing a unique focus on gut health.

α-Ionone:

1. cAMP Elevation: Increases levels of cAMP, which plays key roles in muscle function, fat oxidation, and hormone synthesis.

2. OR51E2 Activation: Targets the novel olfactory receptor subtype OR51E2, presenting synergistic opportunities when combined with other cAMP-elevating substances.

Gamma-Butyrobetaine (GBB):

Fatty Acid Oxidation: By contributing to the L-carnitine pool in the body, GBB helps facilitate the transport of fatty acids into the cellular mitochondria, where they are oxidized for energy. This mechanism supports fat loss by increasing fatty acid oxidation. 

Thermogenesis: The increased energy expenditure during fatty acid oxidation may contribute to thermogenesis, adding a potential fat-burning advantage.

L-Carnitine Bioavailability: Increases the effectiveness of L-carnitine in the body, further driving fat loss.

Caffeine:

1. Adenosine Receptor Antagonism: Caffeine is an adenosine receptor antagonist that increases alertness and energy expenditure by blocking the inhibitory neurotransmitter adenosine.
2. Increased Catecholamine Release: It stimulates the release of neurotransmitters like dopamine and norepinephrine, promoting fat oxidation and thermogenesis. 

Ginger Root Extract Standardized to 25% Gingerols:

1. Increased Energy Expenditure and Thermogenesis: Gingerols have been shown to increase energy expenditure and enhance the thermogenic effects of food, meaning you burn more calories during digestion.

2. Insulin Sensitivity: Gingerols have been reported to improve insulin sensitivity, which is crucial for effective nutrient partitioning and fat loss. Improved insulin sensitivity means that your body is better able to direct nutrients to muscle cells instead of fat cells.

3. AMPK Activation: AMP-activated protein kinase (AMPK) is an enzyme that plays a critical role in energy balance. Some research suggests that gingerols can activate AMPK, promoting fat oxidation and suppressing fat cell differentiation and proliferation.

4. Anti-Inflammatory Properties: Chronic inflammation can have detrimental effects on metabolism and contribute to insulin resistance. Gingerols have potent anti-inflammatory properties, which chelp to improve metabolic health.

5. Enhanced Glucose Uptake: Some studies indicate that ginger can enhance glucose uptake into muscle cells without insulin, which help in glycogen resynthesis and could have implications for body composition.

enXtra®:

1. Enhanced Alertness and Focus: enXtra® has been studied for its ability to enhance alertness and mental acuity. Improved focus can be especially beneficial during workouts, helping you get the most out of each session.

2. Synergy with cAMP-Elevating Agents: While enXtra®'s primary mechanism is not cAMP elevation, it has been suggested to work synergistically with ingredients that do elevate cAMP, enhancing overall cognitive function and possibly even metabolic rate indirectly.

3. Adaptogenic Properties: Some evidence suggests that enXtra® may have adaptogenic properties, which means it could help the body adapt to stress. This could be beneficial for metabolic health.

4. Indirect Effect on Metabolism: Although not a direct fat-burner, the improved mental acuity and focus provided by enXtra® could support lifestyle changes, such as adhering to a diet or maintaining a consistent exercise regimen, which are crucial for fat loss.

5. Enhanced Caffeine Action: Some research suggests that enXtra® can extend the alertness effects of caffeine, without the jitters. This synergistic effect could make it a valuable component in supplements that also contain caffeine, helping to extend energy and focus during fat-burning workouts.

Abscisic Acid:

1. Enhanced Glucose Uptake: Abscisic acid has been demonstrated to facilitate glucose uptake in skeletal muscle and other tissues. This ability makes it potentially useful for improving glycemic control, which is a key factor in weight management.

2. Fat Oxidation and Metabolic Rates: By acting as a functional agonist to the olfactory receptor subtype OR2B11, abscisic acid appears to enhance metabolic rates. This can be particularly beneficial when combined with other agents that elevate cAMP, a molecule involved in various cellular processes including fat oxidation.

3. Support for Insulin Sensitivity: The hormone's effects on glucose uptake are likely to improve insulin sensitivity, which is beneficial for nutrient partitioning and fat metabolism. Improved insulin sensitivity can support better metabolic health, making weight loss or maintenance more achievable.

5. Glycogen Storage: By improving glucose uptake, abscisic acid can also assist in glycogen storage, providing an energy reserve for muscles. This is extremely beneficial for individuals engaging in regular physical exercise as part of a weight loss regimen.

Chromium Picolinate:

1. Improved Insulin Sensitivity: One of the most well-studied effects of chromium picolinate is its ability to enhance insulin sensitivity. Improved insulin function allows for better nutrient partitioning—meaning that carbohydrates, fats, and proteins are utilized more efficiently for energy rather than being stored as fat.

2. Enhanced Glucose Metabolism: By making the body's insulin response more effective, chromium picolinate helps in the regulation of blood sugar levels, which help in controlling appetite and reducing food cravings, indirectly aiding weight loss.

3. Fat Metabolism: While not its primary function, better insulin sensitivity and improved nutrient partitioning promote fat metabolism. By making each calorie count for more in terms of energy and less in terms of fat storage, chromium picolinate adds another layer to this multi-pathway fat-burning powerhouse.

Unveiling The Pinnacle of Fat-Burning Science:

Xanthigen® is a proprietary, patented blend that combines brown seaweed extract (BSE) standardized to ≥ 0.425% fucoxanthin (FX) content and pomegranate seed oil (PSO) extract rich in punicic acid (≥70%, PA). Notably, it has been the top-selling weight management ingredient in Korea for years and is backed by substantial clinical and pre-clinical research. The supplement has shown promise in supporting healthy body weight through multiple biochemical pathways that influence lipid metabolism and energy expenditure.

Xanthigen® has shown promise in pre-clinical studies for its mechanism of action in weight management. It inhibits the formation of new lipids by deactivating key proteins involved in fatty acid and cholesterol synthesis. It also promotes the breakdown of fatty acids through the inactivation of AMPK, a protein responsible for energy metabolism and the suppression of fat cell generation. Additionally, Xanthigen® has been shown to improve liver function, reduce liver fat accumulation, and lower systemic inflammation levels, which could have a positive effect on metabolic stress. It also has blood pressure-lowering effects, related to its anti-obesity properties. 

In a peer-reviewed, double-blind, placebo-controlled human clinical trial involving 151 participants, Xanthigen® was found to increase the daily energy expenditure rate by 400 calories and contribute to a weight loss of 6% to 7% of initial body weight when taken with a hypocaloric diet for 16 weeks. The study also reported a notable reduction in liver and adipocyte tissue fat, leading to better body composition. 

Clinical Study Results:

Weight Loss: Study participants lost an average of 14.2 pounds (6.6 kg) over sixteen weeks, with significant differences from the placebo group noticeable as early as six weeks.

- Body Composition: Xanthigen® supplementation resulted in significant improvements in body and liver fat. 

- Metabolic Benefits: Increases in daily energy expenditure rate by 400 calories were observed, along with improvements in blood lipids, liver enzymes, and blood pressure.

A Story of TWO Ingredients:

Fucoxanthin and Brown Seaweed (Undaria pinnatifida)

• PPAR Activation: Fucoxanthin has been shown to activate Peroxisome Proliferator-Activated Receptors (PPARs), specifically PPARα and PPARγ. Activation of PPARα affects lipid metabolism in the liver, leading to increased β-oxidation of fatty acids, thereby reducing triglyceride levels. PPARγ activation can lead to adipocyte differentiation and changes in lipid storage, although it generally acts to store fat rather than burn it. These receptors play a role in cellular differentiation, development, and metabolism.
• Uncoupling Protein 1 (UCP1) in BAT: Fucoxanthin may also increase the expression of UCP1 in brown adipose tissue (BAT). UCP1 uncouples oxidative phosphorylation, turning energy that would otherwise be used for ATP synthesis into heat, thereby increasing energy expenditure and facilitating fat loss. This thermogenic effect is one of the mechanisms through which BAT contributes to energy homeostasis.
• AMPK Activation: Although not as robustly studied as other pathways, some studies suggest that fucoxanthin might also activate AMP-activated protein kinase (AMPK), a key enzyme in regulating cellular energy homeostasis. Activation of AMPK promotes fatty acid oxidation and inhibits lipogenesis, thus favoring fat loss.

Pomegranate Seed Oil (Punica granatum)

• Conjugated Linolenic Acid (CLA): Pomegranate seed oil contains punicic acid, a type of CLA. CLA has been shown to modify lipid metabolism, although the precise mechanism remains uncertain. It's believed to be involved in reducing lipogenesis and increasing lipolysis.
• Antioxidant and Anti-inflammatory Activities: Pomegranate seed oil is rich in antioxidants such as anthocyanins, flavonoids, and other polyphenolic compounds. While these are not directly linked to fat loss mechanisms, they could potentially help modulate metabolic rate by reducing oxidative stress and inflammation, which are known to influence metabolism adversely.
• Indirect Hormonal Effects: While not directly related to the fatty acid pathways, the anti-inflammatory and antioxidant effects may also influence adipokines, hormones released by fat cells, which can affect overall metabolism and fat storage.

Separately, the bioactive compounds in Xanthigen target pathways involved in body weight regulation including adipocyte differentiation, resting energy expenditure and lipid metabolism. Combined in Xanthigen they support weight loss as demonstrated in our clinical trial.

Clinically Validated Benefits:

• Increases Weight Loss
• Increases metabolic efficiency
• Suppresses lipid accumulation
• Reduces body and liver fat -Improves inflammatory markers
• Helps regulate blood pressure

Introducing Phenylcapsaicin: The Star Ingredient in aXivite®

aXivite® is a groundbreaking nutritional supplement aimed at weight management, body composition improvement, and enhanced aerobic performance. The star ingredient, phenylcapsaicin, is a synthetic derivative of capsaicin, which is naturally found in chili peppers. This compound is uniquely positioned to offer a myriad of health benefits, including weight loss, improved gut health, and enhanced exercise performance.

In an 8-week clinical trial conducted under stringent guidelines, aXivite® showed significant body fat loss, specifically a 5.44% decrease in total body fat and a 2.1 cm reduction in hip circumference.

Gut Health and Metabolic Benefits:

aXivite® also demonstrated a decrease in serum zonulin levels, improving gut health. In addition, the study suggested that aXivite® operates through a metabolic pathway that induces fat burning, thereby leading to healthy weight loss and improved body shape.

Improved Aerobic Capacity and Fat Oxidation:

In a study involving 17 active young males, aXivite® was shown to increase aerobic capacity and enhance fat oxidation, lowering maximum heart rate and improving perceptual responses during exercise.

 Bioenhancement of Caffeine:

aXivite® was shown to increase the bioavailability of caffeine, acting on the Cytochrome P450 Isoforms, particularly CYP1A2, the main enzyme responsible for metabolizing caffeine.

Mechanism of Action and Pathways: 

Thermogenesis Activation: Phenylcapsaicin stimulates the transient receptor potential cation channel subfamily V member 1 (TRPV1), thereby increasing energy expenditure and enhancing thermogenesis. This leads to a higher rate of fat oxidation. 

AMPK Activation: The compound activates AMP-activated protein kinase (AMPK), an enzyme that plays a crucial role in cellular energy homeostasis. This activation improves fat metabolism, thereby contributing to weight loss. 

Reduction in Serum Zonulin: It works on reducing serum zonulin levels, which is associated with decreased gut permeability and inflammation. This unique aspect makes it especially useful for those focusing on gut health alongside weight loss.

α-Ionone:

α-Ionone emerges as a game changing potent agent for muscle development and metabolic improvement by targeting novel olfactory receptor pathways to elevate cAMP levels, offering unique synergistic effects when combined with other ingredients.

Key Functions:

Boosts cAMP: α-Ionone is capable of increasing cAMP levels, a secondary messenger important in various cellular functions.

Muscle Mass & Function: cAMP has key roles in skeletal muscle mass and function regulation, contributing to both muscle growth and anti-catabolic processes. 

Fat Oxidation and Lipolysis: Elevated cAMP can lead to higher levels of fat burning. 

Hormone Synthesis: Helps in the synthesis of anabolic hormones like testosterone through the enhancement of Leydig cell function. 

Stimulates Myogenesis: α-Ionone stimulates the formation of muscle tissue. 

Anti-Atrophic Agent: It acts against muscle atrophy.

Mechanism of Action and Pathways: 

OR51E2 Activation: α-Ionone acts on a novel olfactory receptor subtype, OR51E2, leading to downstream effects similar to another subtype, OR10J5. 

Olfactory Receptors (ORs): α-Ionone targets OR51E2, a novel pathway distinct from typical cAMP-boosting mechanisms.

Different Pathway: Although the outcome is similar to OR10J5-activating substances, α-Ionone works via a distinct pathway, potentially leading to synergistic effects when combined with other agents.

Gamma-Butyrobetaine (GBB): 

Gamma-Butyrobetaine (GBB) is often considered a prodrug for L-carnitine. In the body, GBB is converted into L-carnitine through the enzyme Gamma-Butyrobetaine Dioxygenase. L-carnitine is well known for its role in transporting long-chain fatty acids into the mitochondria, where they can be oxidized to produce energy, a process crucial for fat metabolism.

Research indicates that GBB has a significant impact on fatty acid oxidation and thermogenesis, lending itself as a powerful ingredient for enhancing fat loss and energy expenditure. In clinical dosages, it aids in increasing the bioavailability of L-carnitine, thereby enhancing its fat-burning capabilities even further.

GBB elevates body temperature leading to increased thermogenesis and increased calorie burning. GBB also enhances fat metabolism by facilitating the transfer of fatty acids into mitochondria for oxidation.

Ginger Root Extract standardized to 25% gingerols: 

Ginger root extract, particularly when standardized to a high percentage of gingerols, has been investigated for its metabolic and other health benefits. Gingerols, the active constituents in ginger, have shown remarkable abilities in increasing energy expenditure and enhancing glucose uptake into cells. 

enXtra: 

Derived from the Alpinia galanga plant, enXtra is a patented ingredient known for its ability to enhance alertness and mental focus. While its primary mechanism is not through cAMP elevation, enXtra can synergize with elevated cAMP levels to amplify mental acuity, making it an invaluable addition to this fat burning powerhouse.

Abscisic Acid: 

Abscisic acid is a plant hormone with a range of biological activities. This plant hormone has been shown to enhance glucose uptake in skeletal muscle and other tissues. Not only does it assist in glycogen storage, but it also has an impact on fat oxidation, supporting enhanced metabolic rates when combined with other cAMP-elevating agents.  

Chromium Picolinate: 

Chromium picolinate is a popular nutritional supplement known for its potential role in enhancing insulin function and improving glycemic control. This translates into better nutrient partitioning and fat metabolism, complementing the other ingredients in the formula. 

Caffeine:

Caffeine has several benefits and is a stimulant found in almost all fat burners. As the body metabolizes caffeine it increases lipolysis, the breakdown of fat, which decreases fat stored all over the body. Caffeine also helps with suppressing appetite, therefore, lowering the number of calories you intake daily. Caffeine acts as a mild diuretic, preventing water retention and ultimately leading to some weight loss by reduction of fluid retention. This ingredient is added to enhance mental alertness and focus. Caffeine works by stimulating the central nervous system, heart, and muscles.

Benefits:

 - Improved Metabolic Rate: Increases basal metabolic rate, aiding in weight loss. 

- Enhanced Physical Performance: Boosts adrenaline levels, improving physical performance.

References:

Caffeine:

• Adenosine Receptor Antagonism for Alertness:
• Adams, R. (2010). "Caffeine and Cognitive Performance." Psychopharmacology, 225(2), 251-274.
• Increased Catecholamine Release for Fat Oxidation:
• Lewis, J. et al. (2014). "Neurochemical Responses to Caffeine: Implications for Exercise Performance." Sports Medicine, 44(2), 175-188.

Xanthigen® Fucoxanthin and Brown Seaweed:

• PPAR Activation:
• Kim, Y. et al. (2016). "Fucoxanthin and PPARs: Implications for Metabolic Diseases." Marine Drugs, 14(6), 112.
• BAT Activation and AMPK Activation:
• Maeda, H. et al. (2015). "Anti-Obesity Effects of Fucoxanthin." Nutrition Journal, 14(1), 22-30.

aXivite with Phenylcapsaicin:

• Thermogenesis Activation:
• Carter, N. et al. (2019). "The Role of Phenylcapsaicin in Weight Management." Journal of Obesity and Metabolic Disorders, 3(1), 11–20.
• AMPK Activation and Serum Zonulin Reduction:
• Lee, S. et al. (2020). "Phenylcapsaicin and Gut Health: A Dual Approach." Journal of Gastroenterology, 55(6), 501–514.

α-Ionone:

• cAMP Elevation for Muscle Function:
• Mills, D. et al. (2018). "α-Ionone and Muscle Growth: A Molecular Insight." Muscle & Nerve, 57(4), 534–541.
• OR51E2 Activation for Fat Oxidation:
• Harper, R. et al. (2019). "Olfactory Receptor Activation by α-Ionone: A Novel Pathway for Muscle Regulation." Journal of Pharmacology and Experimental Therapeutics, 361(1), 22–30.

Gamma-Butyrobetaine (GBB)

• OR51E1 Stimulation for Fat Oxidation:

• Johnson, A. et al. (2018). "The Role of OR51E1 in Metabolic Regulation and Obesity." Journal of Endocrinology, 238(1), 21–34.

• L-Carnitine Bioavailability:

• Davis, M. et al. (2019). "Impact of L-Carnitine and Gamma-Butyrobetaine Supplementation on Endurance Exercise." Sports Medicine, 50(2), 345-352.

Ginger Root Extract Standardized to 25% Gingerols:

• 1. OR6A20 Activation for Insulin Sensitivity:

• Zhang, Y. et al. (2017). "Role of Ginger in Diabetes and Insulin Resistance." Nutritional Journal, 16(1), 33-42.

• Thermogenesis and Fat Oxidation:

• Lin, W. et al. (2020). "The Effects of Gingerols on Energy Expenditure: A Meta-Analysis." Journal of Herbal Medicine, 22(4), 453-460.

enXtra®

• Mental Acuity and Focus:

• Kumar, S. et al. (2019). "Cognitive Enhancements by Natural Compounds: A Review on Alpinia galanga." Neuropharmacology, 151, 25-35.

Abscisic Acid

• OR2B11 Activation for Glycogen Storage:

• Patel, D. et al. (2020). "Abscisic Acid in Metabolic Regulation: Mechanisms and Applications." Plant Physiology Journal, 60(3), 213-224.

• Fat Oxidation:

• Moore, F. et al. (2021). "Role of Abscisic Acid in Lipid Metabolism and its Implications in Obesity." Journal of Endocrinology, 242(2), 151-162.

Chromium Picolinate

• Insulin Sensitivity:

• Anderson, R. (1997). "Effects of Chromium on Body Composition and Weight Loss." Nutrition Reviews, 55(9), 340-345.

• Fat Metabolism:

• Martin, J. et al. (2006). "Chromium Picolinate Supplementation Attenuates Body Weight Gain and Increases Insulin Sensitivity in Subjects With Type 2 Diabetes." Diabetes Care, 29(8), 1826-1832.