AlphaDefy by Olympus Labs

AlphaDefy by Olympus Labs

DEFY Limits. DEFY Boundaries. DEFY Expectations! It's Time to Take CONTROL and Unlock Your Genetic Potential!

Ever wondered what it would be like to break through the glass ceiling of your physical limitations? The barrier that hinders muscle growth, stops fat loss, and caps your athletic performance? Those days are over. Turn your impossible dream into an attainable reality. Get ready for muscle growth and fat loss like you've never experienced before. Let's usher in the age of body recomposition!

…Say hello to ALPHADEFY!

What does AlphaDefy do?

This powerful new formula from Olympus Labs has been meticulously crafted to activate multiple PPAR pathways, namely PPAR-Alpha, PPAR-Beta, PPAR-Delta, and PPAR-Gamma, each of which plays a pivotal role in your metabolism and muscle growth. 

What are PPARs?

PPARs are like the overseers in your body that supervise how it deals with fat and sugar:

• PPAR-Alpha: Encourages the body to break down fat for energy. Great for reducing fat stores and is especially active during fasting or exercise.
• PPAR-Beta/Delta: Focused on endurance and increased stamina, it helps muscles burn fat efficiently. Useful for longer periods of activity like running or cycling. Imagine longer workouts with less fatigue—that's what ALPHADEFY can do for you.
• PPAR-Gamma: This one is a bit of a regulator. It helps manage how the body uses sugar and stores fat, playing a role in energy balance and sensitivity to insulin, the hormone that controls blood sugar levels.
  
  

This groundbreaking formula goes beyond merely activating multiple PPAR pathways. It elevates energy expenditure to unprecedented heights by stimulating brown adipose tissue (BAT) and engaging various other metabolic routes unlocking the potential for concurrent muscle growth, fat loss, anabolism, and metabolic optimization.

AlphaDefy doesn't just break the chains—it shatters them, enabling you to achieve a transformative level of body recomposition.

Key Benefits of AlphaDefy:

• Comprehensive Metabolic Enhancement: AlphaDefy's integrated approach targets multiple aspects of metabolic health, including improved insulin sensitivity, enhanced fat oxidation, and optimized energy utilization, thanks to the synergistic action of its key ingredients.
• Inflammation and Oxidative Stress Reduction: The formula contains anti-inflammatory and antioxidant components that help reduce inflammation and oxidative stress, supporting overall health and recovery.
• Boosted Energy and Endurance: Ingredients like L-Baiba and γ-Mangostin are designed to increase energy and endurance by enhancing fat oxidation and energy utilization, allowing for more intense and prolonged physical activities.
• Enhanced Fat Loss and Muscle Regeneration: The combination of ingredients in AlphaDefy supports synergistic fat loss, increased stamina, and enhanced muscle regeneration, setting the stage for effective body recomposition.
• Improved Lipid Profiles and Insulin Resistance: The formula aims to improve lipid profiles and insulin resistance, contributing to better blood sugar regulation and cardiovascular health.
• Whole-Body Metabolic Boost: By targeting multiple metabolic pathways, AlphaDefy provides a comprehensive boost to the body's metabolism, aiding in weight management and overall metabolic health.
• Thermogenic Activation: Ingredients like Mitoburn L-Baiba activate brown adipose tissue (BAT), turning the body into a calorie-burning furnace and enhancing thermogenesis for accelerated fat loss.
• Conversion of White to Brown Fat: The formula has the potential to convert white adipose tissue (WAT) into energy-burning brown fat (BAT), further enhancing the body's fat-burning capabilities.
• Improved Muscle Performance: By improving fatty acid utilization in skeletal muscles, AlphaDefy enhances endurance and performance, making it effective for both shredding and bulking phases.
• Overall Health Benefits: In addition to its metabolic and performance-enhancing effects, AlphaDefy's ingredients offer a range of health benefits, including anti-inflammatory effects, antioxidant properties, and improved insulin sensitivity, contributing to long-term well-being and health.
  
  

Key Ingredients of AlphaDefy:

• Garcinia Mangostana L. (peel) Extract (1500mg): This is extracted from the peel of the mangosteen fruit, known for its high content of xanthones like α-mangostin and γ-mangostin. These compounds have been researched for their potential antioxidant properties and their ability to support lipid metabolism and energy utilization.
• MitoBurn™ (L-β-Aminoisobutyric Acid) (500mg): MitoBurn™ is a branded form of L-β-Aminoisobutyric Acid, which is believed to help convert white adipose tissue into brown adipose tissue, potentially enhancing thermogenesis and fat oxidation. It's often referred to as an exercise mimetic because it may replicate some benefits of exercise at the cellular level.
• Artemisia Iwayomogi Extract (300mg): Standardized for dibromo-4-methoxybiphenyl, this extract comes from a plant traditionally used in Korean medicine. It's included for its potential to activate PPAR-Delta, a regulator of lipid metabolism, which could support increased fat burning and improved endurance.
• Genistein (50mg): A potent isoflavone, Genistein is included for its potential role as a PPAR-Beta activator, which might enhance fatty acid oxidation and support muscle growth.
• Selective Fat Ignition System (25mg): This system is a blend that includes Inulin, Chromium Picolinate as Chromax®, and Avocado (Persea americana) extract. Chromium Picolinate is known for its role in enhancing insulin sensitivity, while Avocado extract standardized to Abscisic Acid could help with glucose management and have anti-inflammatory effects. Inulin is a type of fiber that supports digestive health and may have an indirect effect on weight management.

Suggested Use for AlphaDefy:

Take 1 serving (3 capsules) with water 30-45 minutes before training. 

On non-training days, take 1 serving on an empty stomach before breakfast or meal 1. 

Do not exceed 1 serving in a 24-hour period.
Read the entire label before use and follow directions provided.

For optimal results, take AlphaDefy consistently for a period of up to 8 weeks.

Deep Dive Into The Science Behind The Key Ingredients in AlphaDefy:

The key ingredients in AlphaDefy are designed to work synergistically within the formula to support a comprehensive approach to body recomposition, targeting various metabolic pathways to promote fat loss, muscle growth, and overall metabolic health.

Here’s some more details about the key ingredients used in the unique formula of AlphaDefy:

Garcinia Mangostana L. (peel) Extract:

Known for its rich content of α-Mangostin and γ-Mangostin. These xanthone compounds have been traditionally used in Southeast Asian medicine and are recognized for their ability to offer a wide range of health benefits.

α-Mangostin is particularly noted for its activation of the PPAR-γ pathway, which plays a significant role in lipid metabolism and glucose regulation. This activation helps in managing blood sugar levels and optimizing fat storage, making it a valuable asset for metabolic control. Additionally, α-Mangostin possesses anti-inflammatory and antioxidant properties, contributing to overall cellular health.

On the other hand, γ-Mangostin stands out for its dual activation of PPAR-α and PPAR-δ, leading to enhanced fat oxidation, improved lipid profiles, and increased energy utilization. This dual action supports better energy management and endurance, making it a powerful ingredient for those looking to boost their metabolism.

Together, α-Mangostin and γ-Mangostin provide a comprehensive approach to metabolic health, working synergistically to improve insulin sensitivity, control inflammation, and enhance antioxidant protection. Their combined effects make Garcinia Mangostana L. Extract a crucial ingredient in AlphaDefy, contributing to its effectiveness in promoting overall metabolic health and body recomposition.

MitoBurn™ (L-β-Aminoisobutyric Acid):

Mitoburn L-Baiba is a powerful amino acid derivative that revolutionizes metabolic health and muscle optimization. It has the remarkable ability to transform white adipose tissue (WAT), which stores energy, into brown adipose tissue (BAT), which burns energy, effectively turning fat-storing cells into fat-burning machines.

L-Baiba, often referred to as "Exercise in a Pill," is released during exercise and is linked to the activation of PPAR alpha by the protein PGC1 alpha. This process leads to various benefits, including the browning of white fat, enhanced fat breakdown, and improved metabolism. It also helps in reducing fat mass and may counteract leptin deficiency, which is associated with obesity.

Overall, Mitoburn L-Baiba is a key ingredient in AlphaDefy, potentially redefining muscle building, body recomposition, and fat loss by activating metabolic pathways and transforming the way the body stores and uses fat.

Artemisia Iwayomogi Extract:

Dibromo-4-methoxybiphenyl is a naturally occurring compound found in the Korean herb Artemisia Iwayomogi, also known as Haninjin. It has a long history of safe consumption in traditional Korean medicine and cuisine. This compound is a key ingredient in AlphaDefy, known for its unique ability to activate PPAR-Delta, a crucial regulator in lipid metabolism.

The activation of PPAR-Delta by Dibromo-4-methoxybiphenyl leads to increased fat burning, enhanced weight management, and improved endurance. It does this by boosting the breakdown of fatty acids in skeletal muscles, protecting against diet-induced weight gain, and switching the body's energy source from carbohydrates to fats.

In addition to its weight management benefits, Dibromo-4-methoxybiphenyl also helps improve insulin sensitivity, which is beneficial for diabetes management, reduces blood sugar levels, and lowers triglycerides in the blood. This makes it a valuable component of AlphaDefy for those looking to improve their metabolic health and manage their weight effectively.

Genistein:

Genistein is a bioactive compound from the isoflavone family that plays a crucial role in AlphaDefy's formula, especially in activating the PPAR-Beta pathway. This unique activation enhances the body's ability to use fat as fuel, leading to unparalleled fat burning and muscle growth. By increasing fatty acid oxidation, Genistein helps eliminate stubborn fat and provides a cleaner, more sustained energy source for muscle cells, resulting in more potent workouts and significant muscle development.

What sets Genistein apart is its synergistic effect when combined with other ingredients in AlphaDefy that target PPAR-Alpha, PPAR-Delta, and PPAR-Gamma pathways. This combination amplifies the formula's overall potency, transforming the efficiency of muscle cells from merely burning sugar to effectively obliterating fat. The inclusion of Genistein in AlphaDefy ensures a comprehensive approach to metabolic enhancement, making it more than just a supplement—it's a key to unlocking a new level of human potential in fitness and body recomposition.

Selective Fat Ignition System:

This system comprises a blend of Inulin, Chromium Picolinate (as Chromax®), and Avocado extract standardized to Abscisic Acid. Chromium Picolinate is known for supporting insulin efficiency and metabolic rate enhancement. Abscisic Acid has properties that could aid in glucose management and anti-inflammatory effects, while Inulin serves as a prebiotic fiber promoting gut health and contributing indirectly to weight management.

AlphaDefy by Olympus Labs: Elevate your performance, redefine your physique, and DEFY your limits with the ultimate tool for body recomposition.

References: 

 PPAR Pathways:

1. Issemann, I., & Green, S. (1990). Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature, 347(6294), 645-650.
2. Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., & Wahli, W. (1999). Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. Journal of Clinical Investigation, 103(11), 1489-1498.
   
   

 Mitoburn L-Baiba

1. Roberts, L. D., Boström, P., O'Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., ... & Gerszten, R. E. (2014). β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metabolism, 19(1), 96-108.
2. Mottillo, E. P., Desjardins, E. M., Crane, J. D., Smith, B. K., Green, A. E., Ducommun, S., ... & Steinberg, G. R. (2016). Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function. Cell Metabolism, 24(1), 118-129.
   
   

 WAT to BAT Conversion

1. Wu, J., Boström, P., Sparks, L. M., Ye, L., Choi, J. H., Giang, A. H., ... & Spiegelman, B. M. (2012). Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell, 150(2), 366-376.
   
   

Anti-Inflammatory Effects

1. Lee, W. J., Tateya, S., Cheng, A. M., Rizzo-DeLeon, N., Wang, N. F., Handa, P., ... & Kim, F. (2013). M2 macrophage polarization mediates anti-inflammatory effects of endothelial nitric oxide signaling. Diabetes, 62(8), 3024-3033.
   
   

Endurance and Performance

1. Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y. X., Banayo, E., ... & Evans, R. M. (2008). AMPK and PPARδ agonists are exercise mimetics. Cell, 134(3), 405-415.
   
   

α-Mangostin and γ-Mangostin

1. Gutierrez-Orozco, F., & Failla, M. L. (2013). Biological activities and bioavailability of mangosteen xanthones: a critical review of the current evidence. Nutrients, 5(8), 3163-3183.
2. Chen, L. G., Yang, L. L., & Wang, C. C. (2008). Anti-inflammatory activity of mangostins from Garcinia mangostana. Food and Chemical Toxicology, 46(2), 688-693.
   
   

PPAR-γ Activation and α-Mangostin

3. Lee, Y. S., Cha, B. Y., Choi, S. S., & et al. (2012). Effects of a Garcinia mangostana Linn. extract on adipogenesis in 3T3-L1 adipocytes. Journal of Ethnopharmacology, 142(2), 359-371.
   
   

 Improved Insulin Sensitivity

4. Ahmadian, M., Suh, J. M., Hah, N., Liddle, C., Atkins, A. R., Downes, M., & Evans, R. M. (2013). PPARγ signaling and metabolism: the good, the bad and the future. Nature Medicine, 19(5), 557-566.
   
   

Anti-Inflammatory Benefits

5. Rahman, M. M., Fazlic, V., & Saad, N. W. (2013). Xanthones from mangosteen extracts as natural chemopreventive agents: potential anticancer drugs. Current Molecular Medicine, 13(10), 1477-1486.
   
   

 γ-Mangostin: Dual PPAR-α and PPAR-δ Activation

6. Wang, L., Waltenberger, B., Pferschy-Wenzig, E. M., Blunder, M., Liu, X., Malainer, C., ... & Atanasov, A. G. (2014). Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review. Biochemical Pharmacology, 92(1), 73-89.
   
   

 Fat Oxidation & Lipid Control

7. Desvergne, B., & Wahli, W. (1999). Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocrine Reviews, 20(5), 649-688.
   
   

 Increased Energy & Endurance

8. Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y. X., Banayo, E., ... & Evans, R. M. (2008). AMPK and PPARδ agonists are exercise mimetics. Cell, 134(3), 405-415.
   
   

Genistein and PPAR-Beta Activation

9. Dang, Z. C., & Lowik, C. W. G. M. (2005). Dose-dependent effects of phytoestrogens on bone. Trends in Endocrinology & Metabolism, 16(5), 207-213.
10. Mezei, O., Banz, W. J., Steger, R. W., Peluso, M. R., Winters, T. A., & Shay, N. (2003). Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells. The Journal of Nutrition, 133(5), 1238-1243.
    
    

 Synergistic Benefits

11. Lee, C. H., Olson, P., & Evans, R. M. (2003). Minireview: Lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology, 144(6), 2201-2207.
    
    

Abscisic Acid:

1. Bruzzone, S., Ameri, P., Briatore, L., Mannino, E., Basile, G., Andraghetti, G., ... & Zocchi, E. (2008). The plant hormone abscisic acid increases in human plasma after hyperglycemia and stimulates glucose consumption by adipocytes and myoblasts. The FASEB Journal, 22(11), 4152-4160.
2. Guri, A. J., Hontecillas, R., Si, H., Liu, D., & Bassaganya-Riera, J. (2007). Dietary abscisic acid ameliorates glucose tolerance and obesity-related inflammation in db/db mice fed high-fat diets. Clinical Nutrition, 26(1), 107-116.
   
   

 Chromax® Chromium Picolinate:

3. Komorowski, J. R., Juturu, V., & Documentation, Q. (2008). Chromium picolinate does not produce chromosome damage. Toxicology in Vitro, 22(4), 819-826.
4. Anderson, R. A., Cheng, N., Bryden, N. A., Polansky, M. M., Cheng, N., Chi, J., & Feng, J. (1997). Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes, 46(11), 1786-1791.
   
   

Full-Spectrum Metabolic Synergy:

5. Rondanelli, M., Opizzi, A., Solerte, S. B., Trotti, R., Klersy, C., & Cazzola, R. (2011). Administration of a dietary supplement (N-oleyl-phosphatidylethanolamine and epigallocatechin-3-gallate formula) enhances compliance with diet in healthy overweight subjects: A randomized controlled trial. The British Journal of Nutrition, 101(3), 457-464.
6. Desvergne, B., & Wahli, W. (1999). Peroxisome proliferator-activated receptors: Nuclear control of metabolism. Endocrine Reviews, 20(5), 649-688.
   
   

General Metabolic Health:

7. Ahima, R. S., & Flier, J. S. (2000). Leptin. Annual Review of Physiology, 62(1), 413-437.
   
   

Dibromo-4-methoxybiphenyl:

1. Doh EJ, Oh SE Multiplex PCR method to discriminate Artemisia iwayomogi from otherArtemisia plants . Methods Mol Biol. (2012)
2. Cho SY, et al An ethanol extract of Artemisia iwayomogi activates PPARd leading to activation of fatty acid oxidation in skeletal muscle . PLoS One. (2012)
3. Kleiner S1, Nguyen-Tran V, Baré O, Huang X, Spiegelman B, Wu Z. PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function. J Biol Chem. 2009 Jul 10;284(28):18624-33. doi:10.1074/jbc.M109.008797. Epub 2009 May 12.
4. Embler, Emi Kanakubo, Ph.D., PPARdelta activation enhances skeletal muscle regeneration UNIVERSITY OF CALIFORNIA, SAN DIEGO, 2012, 93 pages; 3494293
5. Brunmair B, Staniek K, Dorig J, Szocs Z, Stadlbauer K, et al. Activation of PPAR-delta in isolated rat skeletal muscle switches fuel preference from glucose to fatty acids. Diabetologia. 2006;49:2713–2722. [PubMed]